Erika Ramos Silva, Fernanda Oliveira de Carvalho, Luciana Garcez Barretto Teixeira, Nayara Gomes Lima Santos, Fernanda Araújo Felipe, Hericalizandra Santa Rosa Santana, Saranavan Shanmugam, Lucindo José Quintans Júnior, Adriano Antunes de Souza Araújo and Paula Santos Nunes* Pages 3454 - 3465 ( 12 )
Carvacrol has a high therapeutic potential, with in vitro studies showing promising results in different cellular models using a variety of methodological designs. Therefore, the objective of this study was to conduct a systematic review to analyze the pharmacological effects of carvacrol in in vitro studies. A comprehensive search of the literature was made using four databases: Science Direct, Scopus, MEDLINE-PubMed, and Web of Science using different combinations of the following keywords: carvacrol, drug therapy, therapeutic uses, in vitro study. The search of the databases was for studies conducted in the period up to and including September 2016. A total of 3,269 studies were initially identified, with only 31 meeting the inclusion criteria. The included studies contained a variety of in vitro models able to determine the properties of Carvacrol. The following properties of Carvacrol were identified: antimicrobial (7 studies), bactericidal (4), bactericidal and antifungal (1), antiinflammatory (4), anticancer (4), mutagenic (4), antioxidant (3), antifungal (3), antidepressant (1), as a modulator of nerve impulses (1) and an immunological modulator (1). The In vitro studies with Carvacrol included in this review showed a diversity of models and confirmed the therapeutic potential of this product in relation to several diseases.
Carvacrol, monoterpene, natural product, pharmacology, in vitro models, antimicrobial.
Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE