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A Review on Hematopoietic Stem Cell Treatment for Epilepsy

[ Vol. 20 , Issue. 7 ]

Author(s):

Mohan Krishna Ghanta, Neha Merchant and VKS Lakkakula Bhaskar*   Pages 644 - 656 ( 13 )

Abstract:


Epilepsy responds to pharmacotherapy in its initial stages. The response of some forms of epilepsy, like the refractory epilepsy, is extremely low. Surgical management of epilepsy is associated with complications, which necessitates the search for novel and modern strategies for the treatment of epilepsy. Neuroprotection and neuronal regeneration are the major targets that must be accomplished by the new strategies. Hematopoietic Stem Cell (HSCs) therapy for epilepsy has shown promising results in pre-clinical studies with marginal clinical effects. This review explores the characteristics, mechanism of action, and clinical significance of HSCs therapy for the treatment of epilepsy.

Keywords:

Neuroprotection, neuronal regeneration, antiepileptic property, hematopoietic stem cell treatment, epilepsy, seizure.

Affiliation:

Department of Pharmacology, MVJ Medical College & Research Hospital, Hoskote-562 114, Karnataka, Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, Department of Zoology, Guru Ghasidas University, Bilaspur



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