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Effectiveness and Safety Profile of Ginkgo biloba Standardized Extract (EGb761® ) in Patients with Amnestic Mild Cognitive Impairment

[ Vol. 20 , Issue. 4 ]

Author(s):

Ovidiu Băjenaru*, Gabriel Prada, Florina Antochi, Cătălin Jianu, Cătălina Tudose, Adina Cuciureanu, Any Axelerad Docu, Valérie Perrot, Madalina Avram and Cristina Tiu   Pages 378 - 384 ( 7 )

Abstract:


Background: Ginkgo biloba is a common symptomatic treatment for cognitive impairment, although data on its efficacy are controversial.

Objective: The aim of the current study was to evaluate the effectiveness of standardized Ginkgo biloba extract EGb761® (Tanakan® ) for the improvements of cognitive functions over 24 months in a local cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI).

Methods: This multicentre non-interventional study included 500 eligible patients with a MCI treated with 120 mg/day standardized Ginkgo biloba extract EGb761® (Tanakan® ). Patients were evaluated using several scales for assessment of cognition, memory, activities of daily living, and depression (MMSE, FAQ, CGI, HAM-D) at baseline and every 6 months after that for a 24-month period. The median change in MMSE at the 24-month follow-up was the primary outcome of the study.

Results: A statistically significant increase of 2 points in the median MMSE score was obtained. In patients with other concomitant cognitive disorders, the improvement in MMSE was less significant. Tanakan® improved memory impairment (using the delayed recall test) and the ability to accomplish activities of daily living (mean FAQ score, 1.7); it also decreased the severity of depression (mean HAM-D score, 2.4) at the end of the study. More than 80% of the patients showed minimal improvement of their condition as assessed by the CGI-Improvement Scale.

Conclusions: The administration of EGb761® (Tanakan® ) led to a significant improvement of cognitive dec

Keywords:

EGb761® extract, binkgo biloba, Tanakan, MMSE, CGI, HAM-D.

Affiliation:

Department of Neurology, Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Department of Geriatrics and Gerontology, Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Department of Neurology, University Emergency Hospital Bucharest, Bucharest, Department of Neurology, Faculty of Medicine, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Department of Psychiatry, Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Neurology Individual Medical Office, Iasi, Department of Neurology, Faculty of Medicine, University of Medicine and Pharmacy “Ovidius”, Constanta, Medical Department, IPSEN Group, Bucharest, Medical Department, IPSEN Group, Bucharest, Department of Neurology, University Emergency Hospital Bucharest, Bucharest



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