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Functional Neuroproteomics: An Imperative Approach for Unravelling Protein Implicated Complexities of Brain

[ Vol. 20 , Issue. 7 ]


Ibraheem Husain*, Wasim Ahmad*, Abuzer Ali, Laiba Anwar, Sheikh Md Nuruddin, Kamran Ashraf and Mohammad Amjad Kamal   Pages 613 - 624 ( 12 )


A proteome is defined as a comprehensive protein set either of an organ or an organism at a given time and under specific physiological conditions. Accordingly, the study of the nervous system’s proteomes is called neuroproteomics. In the neuroproteomics process, various pieces of the nervous system are “fragmented” to understand the dynamics of each given sub-proteome in a much better way. Functional proteomics addresses the organisation of proteins into complexes and the formation of organelles from these multiprotein complexes that control various physiological processes. Current functional studies of neuroproteomics mainly talk about the synapse structure and its organisation, the major building site of the neuronal communication channel. The proteomes of synaptic vesicle, presynaptic terminal, and postsynaptic density, have been examined by various proteomics techniques. The objectives of functional neuroproteomics are: to solve the proteome of single neurons or astrocytes grown in cell cultures or from the primary brain cells isolated from tissues under various conditions, to identify the set of proteins that characterize specific pathogenesis, or to determine the group of proteins making up postsynaptic or presynaptic densities. It is usual to solve a particular sub-proteome like the heat-shock response proteome or the proteome responding to inflammation. Post-translational protein modifications alter their functions and interactions. The techniques to detect synapse phosphoproteome are available. However, techniques for the analysis of ubiquitination and sumoylation are under development.


Proteome, physiological conditions, neuroproteomics, organelles, functional proteomics, phosphoproteome.


Department of Pharmacology, MESCO Institute of Pharmacy, Amroha, Uttar Pradesh, Department of Pharmacy, Mohammed Al-Mana College for Medical Sciences, Dammam 34222, Department of Pharmacognosy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Department of Pharmacology. School of Pharmaceutical Education & Research, Jamia Hamdard, New-Delhi, Department of Pharmacology. School of Pharmaceutical Education & Research, Jamia Hamdard, New-Delhi, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589

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