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Ethanolamine: A Potential Promoiety with Additional Effects in the Brain

Author(s):

Asfree Gwanyanya, Christie Nicole Godsmark and Roisin Kelly-Laubscher*   Pages 1 - 10 ( 10 )

Abstract:


Ethanolamine is a bioactive molecule found in several cells, including those in the central nervous system (CNS). In the brain, ethanolamine and ethanolamine-related molecules have emerged as prodrug moieties that can promote drug movement across the blood-brain barrier. This improvement in the ability to target drugs to the brain may also mean that in the process ethanolamine concentrations in the brain are increased enough for ethanolamine to exert its own neurological ac-tions. Ethanolamine and its associated products have various positive functions ranging from cell signaling to molecular storage, and alterations in their levels have been linked to neurodegenerative conditions such as Alzheimer’s disease. This mini-review focuses on the effects of ethanolamine in the CNS and highlights the possible implications of these effects for drug design.

Keywords:

Ethanolamine, brain, CNS, phospholipids, prodrug, synaptic, neuromodulator

Affiliation:

Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town,, School of Public Health, College of Medicine and Health, University College Cork, Cork,, Department of Pharmacology and Therapeutics, School of Medicine, College of Medicine and Health, University College Cork, Cork



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