Submit Manuscript  

Article Details


Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis

[ Vol. 20 , Issue. 2 ]

Author(s):

Lina Zhao, Yanxia Gao, Shigong Guo, Xin Lu, Shiyuan Yu, Zeng Zheng Ge, Hua Dong Zhu and Yi Li*   Pages 112 - 124 ( 13 )

Abstract:


Sepsis-associated encephalopathy causes long-term health problems in patients with sepsis. This review explores the pathogenesis of sepsis-associated encephalopathy, including its effects on the blood-brain barrier, microglia activation, mitochondrial dysfunction, the inflammatory medium and neurotransmitters and its roles in amino acid balance disorders, hyperammonemia, and intestinal flora imbalance. Understanding the etiology of sepsis-associated encephalopathy may allow the development of adjunctive therapies targeting its underlying mechanism and help develop preventative strategies.

Keywords:

Hyperammonemia, intestinal flora imbalance, inflammatory medium, neurotransmitters, sepsis-associated encephalopathy, mitochondrial dysfunction.

Affiliation:

Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, Emergency Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Department of Rehabilitation Medicine, Southmead Hospital, Bristol, Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing

Graphical Abstract:



Read Full-Text article