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Herbal Drug Interaction: Mechanistic Details Through the Pharmacokinetic Portfolio

[ Vol. 20 , Issue. 8 ]


Salman Ahmed, Haroon Khan*, Hamed Mirzaei, Muhammad Mohtasheemul Hasan, Mohamed Eddouks and Maria Daglia   Pages 677 - 686 ( 10 )


Background: A large number of individuals today use herbs as a drug alongside medicine and non-physician recommended medications, as herbs are thought to be natural and safe. However, there are many herbs that can potentially interact with other drugs, causing hazardous effects and/or diminished therapeutic effects of other prescriptions.

Objective: It is ought to be comprehended that herbal drugs contain multiple active compounds in different percentages, which can change the enzymatic frameworks, transporters, and, additionally, the physiological processes.

Methods: Different search engines, such as Google Scholar, Scopus, and ScienceDirect, were used for the search of the data on the subject: pharmacokinetic drug interactions with the herbal products.

Results: This worldwide increment in herbal drug popularity has risen with respect to HDIs. These PD or PK interactions are particularly significant for medications. Assessment of herbal drug interaction is difficult because of inconsistency in herbal drug composition and frequently meager information of active constituent pharmacokinetic. These restrictions are bewildered further by the differing points of view concerning herbal product regulation.

Conclusion: It is concluded that a basic assessment of certain pharmacokinetic HDI is needed to settle on educated choices in regard to patient safety. The expanding comprehension of HDPKI will direct more attention to potential interactions.


Herbal medicine, drug interactions, pharmacokinetic mechanisms, active compounds, enzymatic frameworks, drug absorption.


Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi-75270, Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi-75270, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000. Errachidia, Department. of Pharmacy, University of Naples Federico II Via Domenico Montesano 49, 80131 Naples

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