Tahereh Farkhondeh, Haroon Khan, Michael Aschner, Fariborz Samini, Ali M. Pourbagher-Shahri, Hamed Aramjoo, Babak Roshanravan, Christopher Hoyte, Omid Mehrpour and Saeed Samarghandian* Pages 334 - 343 ( 10 )
Deposition of Amyloid-beta (Aβ) peptide in the brain is the leading source of the onset and progression of Alzheimer’s Disease (AD). Recent studies have suggested that anti-amyloidogenic agents may be a suitable therapeutic strategy for AD. The current review was proposed to address the beneficial effects of cannabis-based drugs for the treatment of AD, focusing primarily on Aβ modifications. Keywords related to AD, Aβ, and cannabis-based on MeSH were identified and were searched in PubMed, Google Scholar, Scopus, Ovid-Medline, and Web of Science from inception until 15 March 2020. The full text of identified papers was obtained and assessed based on exclusion and inclusion criteria. The review is based on articles that have focused on AD and the amyloidogenic pathway. A total of 17 studies were identified based on the inclusion criteria; however, nine studies qualified for this systematic review. The maximum and minimum cannabis dosages, mostly CBD and THC in animal studies, were 0.75 and 50 mg/kg, respectively. Cannabis (CBD and THC) was injected for 10 to 21 days. The findings of the 9 articles indicated that cannabis-based drugs might modulate Aβ modifications in several AD models. Our findings establish that cannabis-based drugs inhibited the progression of AD by modulating Aβ modifications.
Amyloid-beta, Alzheimer's disease, cannabis, cannabinoids, cannabidiol, molecular assays.
Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 2091300 Morris Park Avenue, Bronx, NY 10461, Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Student Research Committee, BSc Student in Lab Sciences Technology, Birjand University of Medical Sciences, Birjand, Student Research Committee, Birjand University of Medical Sciences, Birjand, School of Medicine, University of Colorado, Aurora, CO, Arizona Poison & Drug Information Center, the University of Arizona, College of Pharmacy, Tucson, Arizona, AZ, Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur