Panoraia I. Siafaka, Ece Ö. Bülbül, Gökce Mutlu, Mehmet E. Okur, Ioannis D. Karantas and Neslihan Ü. Okur* Pages 360 - 373 ( 14 )
Alzheimer's disease is a neuropathological disease with symptoms such as language problems, confusion as to place or time, loss of interest in activities, which were previously enjoyed, behavioral changes, and memory loss. Alzheimer's disease and other types of dementia affect almost 46.8 million people globally and are estimated to strike about 131.5 million people in 2050. It has been reported that Alzheimer's is the sixth main cause of mortality. The most used drugs, which are currently approved by the Food, and Drug Administration for Alzheimer’s disease are donepezil, rivastigmine, galantamine, memantine, and the combination of donepezil and memantine. However, most of the drugs present various adverse effects. Recently, the transdermal drug delivery route has gained increasing attention as an emerging tool for Alzheimer's disease management. Besides, transdermal drug delivery systems seem to provide hope for the management of various diseases, due to the advantages that they offer in comparison with oral dosage forms. Herein, the current advancements in transdermal studies with potent features to achieve better Alzheimer's disease management are presented. Many researchers have shown that the transdermal systems provide higher efficiency since the first-pass hepatic metabolism effect can be avoided and a prolonged drug release rate can be achieved. In summary, the transdermal administration of Alzheimer's drugs is an interesting and promising topic, which should be further elaborated and studied.
Transdermal, Alzheimer's disease, drug delivery systems, cholinesterase inhibitors, N-methyl-D-aspartate antagonists, neuropathological disease.
Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, Istanbul, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Health Sciences, Istanbul, Department of Pharmacology, Faculty of Pharmacy, University of Health Sciences, Istanbul, Hippokration General Hospital, 2nd Clinic of Internal Medicine, Thessaloniki, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Health Sciences, Istanbul