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A Pivotal Role of the Nrf2 Signaling Pathway in Spinal Cord Injury: A Prospective Therapeutics Study

[ Vol. 19 , Issue. 3 ]


Saeed Samarghandian, Ali Mohammad Pourbagher-Shahri, Milad Ashrafizadeh, Haroon Khan, Fatemeh Forouzanfar, Hamed Aramjoo and Tahereh Farkhondeh*   Pages 207 - 219 ( 13 )


The nuclear erythroid 2-related factor 2 (Nrf2) signaling pathway has a main role against oxidative stress and inflammation. Spinal Cord Injury (SCI) leads to the high secretion of inflammatory cytokines and reactive oxygen species, which disturbs nervous system function and regeneration. Several studies have indicated that the activation of the Nrf2 signaling pathway may be effective against inflammation after SCI. The experimental studies have indicated that many chemical and natural agents act as Nrf2 inducer, which inhibits the SCI progression. Thus, the finding of novel Nrf2- inducer anti-inflammatory agents may be a valuable approach in drug discovery. In the present review, we discussed the Nrf2 signal pathway and crosstalk with the NF-κB pathway and also the impact of this pathway on inflammation in animal models of SCI. Furthermore, we discussed the regulation of Nrf2 by several phytochemicals and drugs, as well as their effects on the SCI inhibition. Therefore, the current study presented a new hypothesis of the development of anti-inflammatory agents that mediate the Nrf2 signaling pathway for treating the SCI outcomes.


Inflammation, nervous system, Nrf2, oxidative stress, spinal cord injury, NQO-1.


Healthy Ageing Research Center, Neyshabur University of Medical Sciences, Neyshabur, Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Student Research Committee, Lab Sciences Technology, Birjand University of Medical Sciences, Birjand, Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand

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