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Oxidative Stress and Role of Neuroimaging Modalities in the Assessment of the Free Radicals Induced Changes in Brain Morphology

Author(s):

Vikas Pareek*, Banshi Nath and Prasun Kumar Roy  

Abstract:


Oxidative stress (OS) the imbalance between the oxidants and antioxidants is the source of injury to proteins, DNA, leading to inflammation, tissue damage and the apoptosis. Neurodegenerative diseases (NDDs) such as Alzheimer's disease, Parkinson's disease, aging-related neuro-degeneration have the imbalance and thus increase in reactive oxygen species in the system. The review article is focused over use of neuroimaging modalities employed in assessment of the structural components of the brain, like Voxel-Based morphometry (VBM) for the volumetric analysis, diffusion tensor imaging (DTI) for the analysis of the white matter tracts, and the magnetic resonance spectroscopy (MRS) analysis dealing with the changes in the chemical composition and thus the structural implications in the neurological disorders, all of these are briefly as well as precisely reviewed thus giving an overview of the role of these neuroimaging modalities in analysis of the oxidative stress induced changes in the neurodegenerative disorders.

Keywords:

Oxidative Stress (OS), Neurodegenerative Diseases (NDDs), Voxel-Based Morphometry (VBM), Diffusion Tensor Imaging (DTI), Magnetic Resonance Spectroscopy (MRS)

Affiliation:

National Brain Research Centre - Computational Neuroscience & Neuroimaging Department Manesar, Haryana, Centre de Recherche CERVO Brain Research Centre, University Laval - Department of Psychiatry and Neuroscience Quebec City, Quebec Cirty, Institute of Technology, B.H.U. - Computational Neuroscience & Neuroimaging Laboratory, School of Bio-Medical Engineering Varanasi, Uttar Pradesh



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