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Bioavailability and Pharmaco-therapeutic Potential of Luteolin in Overcoming Alzheimer’s Disease

[ Vol. 18 , Issue. 5 ]

Author(s):

Fahad Ali and Yasir Hasan Siddique*   Pages 352 - 365 ( 14 )

Abstract:


Luteolin is a naturally occurring, yellow crystalline flavonoid found in numerous dietary supplements we frequently have in our meals. Studies in last 2 decades have revealed its therapeutic potential to reduce the Alzheimer’s disease (AD) symptoms in various in vitro and in vivo studies. The anti-Alzheimer’s potential of luteolin is attributed to its ability to suppress Aβ as well as tau aggregation or promote their disaggregation, down-regulate the expression of COX-2, NOS, MMP-9, TNF-α, interleukins and chemokines, reduce oxidative stress by scavenging ROS, modulate the activities of transcription factors CREB, cJun, Nrf-1, NF-κB, p38, p53, AP-1 and β-catenine and inhibiting the activities of various protein kinases. In several systems luteolin has been described as potent antioxidant and anti-inflammatory agent. In addition we have also discussed about the bio-availability of the luteolin in the plasma. After being metabolized luteolin persists in plasma as glucuronides and sulphate-conjugates. Human clinical trials indicated no dose limiting toxicity when administered at a dose of 100 mg/day. Improvements in the formulations and drug delivery systems may further enhance the bioavailability and potency of luteolin. The current review describes in detail the data supporting these studies.

Keywords:

Luteolin, Alzheimer’s disease, oxidative stress, bioavailability, ROS, Pharmaco-therapeutic.

Affiliation:

Department of Zoology, Aligarh Muslim University, Aligarh-202002, Department of Zoology, Aligarh Muslim University, Aligarh-202002



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