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Causes and Consequences of MicroRNA Dysregulation Following Cerebral Ischemia-Reperfusion Injury

[ Vol. 18 , Issue. 3 ]


Fatemeh Forouzanfar, Mana Shojapour, Samira Asgharzade* and Elham Amini   Pages 212 - 221 ( 10 )


Stroke continues to be a major cause of death and disability worldwide. In this respect, the most important mechanisms underlying stroke pathophysiology are inflammatory pathways, oxidative stress, as well as apoptosis. Accordingly, miRNAs are considered as non-coding endogenous RNA molecules interacting with their target mRNAs to inhibit mRNA translation or reduce its transcription. Studies in this domain have similarly shown that miRNAs are strongly associated with coronary artery disease and correspondingly contributed to the brain ischemia molecular processes. To retrieve articles related to the study subject, i.e. the role of miRNAs involved in inflammatory pathways, oxidative stress, and apoptosis in stroke from the databases of Web of Science, PubMed (NLM), Open Access Journals, LISTA (EBSCO), and Google Scholar; keywords including cerebral ischemia, microRNA (miRNA), inflammatory pathway, oxidative stress, along with apoptosis were used. It was consequently inferred that, miRNAs could be employed as potential biomarkers for diagnosis and prognosis, as well as therapeutic goals of cerebral ischemia.


MiRNAs, stroke, inflammatory pathways, oxidative stress, apoptosis, pathophysiology.


Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, UKM Medical Centre [HUKM], Department of Medicine, Faculty of Medicine

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