Xiaolin Deng, Yangmei Xie and Yinghui Chen* Pages 728 - 735 ( 8 )
Background & Objective: Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately one-third of patients are refractory to these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in the brain has recently been shown to regulate the expression and/or function of ABC transporters in the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular signalling pathways.
Conclusion: Therefore, in this review, we will briefly summarize recent research advances regarding the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy.
Refractory epilepsy, ABC transporter, P-glycoprotein, breast cancer resistance protein, multidrug resistanceassociated protein, neuroinflammation, NF-κB, drug resistance.
Department of Neurology, Jinshan Hospital, Fudan University, Shanghai, Department of Neurology, Jinshan Hospital, Fudan University, Shanghai, Department of Neurology, Huashan Hospital North, Fudan University, Shanghai