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Effect of Neuroinflammation on ABC Transporters: Possible Contribution to Refractory Epilepsy

[ Vol. 17 , Issue. 10 ]

Author(s):

Xiaolin Deng, Yangmei Xie and Yinghui Chen*   Pages 728 - 735 ( 8 )

Abstract:


Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately one-third of patients are refractory to these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in the brain has recently been shown to regulate the expression and/or function of ABC transporters in the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular signalling pathways. Therefore, in this review, we will briefly summarize recent research advances regarding the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy.

Keywords:

Refractory epilepsy, ABC transporter, P-glycoprotein, breast cancer resistance protein, multidrug resistanceassociated protein, neuroinflammation, NF-κB, drug resistance.

Affiliation:

Department of Neurology, Jinshan Hospital, Fudan University, Shangha, Department of Neurology, Jinshan Hospital, Fudan University, Shangha, Department of Neurology, Huashan Hospital North, Fudan University, Shanghai



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