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Effect of Neuroinflammation on ABC Transporters: Possible Contribution to Refractory Epilepsy

[ Vol. 17 , Issue. 10 ]

Author(s):

Xiaolin Deng, Yangmei Xie and Yinghui Chen*   Pages 728 - 735 ( 8 )

Abstract:


Background & Objective: Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately one-third of patients are refractory to these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in the brain has recently been shown to regulate the expression and/or function of ABC transporters in the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular signalling pathways.

Conclusion: Therefore, in this review, we will briefly summarize recent research advances regarding the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy.

Keywords:

Refractory epilepsy, ABC transporter, P-glycoprotein, breast cancer resistance protein, multidrug resistanceassociated protein, neuroinflammation, NF-κB, drug resistance.

Affiliation:

Department of Neurology, Jinshan Hospital, Fudan University, Shanghai, Department of Neurology, Jinshan Hospital, Fudan University, Shanghai, Department of Neurology, Huashan Hospital North, Fudan University, Shanghai

Graphical Abstract:



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