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The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene

[ Vol. 17 , Issue. 8 ]


Viktor S. Kokhan, Tat`yana G. Kokhan, Anna N. Samsonova, Vladimir P. Fisenko, Aleksey A. Ustyugov and Gjumrakch Aliev*   Pages 604 - 607 ( 4 )


Background: It was previously shown that inactivation of gamma-synuclein which is a small soluble neuronal protein affects psycho-emotional status and cognitive abilities in knock-out mice.

Objective: Determine the role of gamma-synuclein inactivation on memory performance in aging animals.

Method: We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein knock-out mice.

Results: As a result, we found moderate aging-unlinked deficit of dopaminergic neurotransmitter system of gamma-synuclein knock-out mice. At the same time, the evidence of progressive synaptic vesicle trafficking machinery impairment was obtained.

Conclusion: Therefore most likely these dysfunctions are associated with a reduction in the highefficient learning performance in tests that require intact working memory.


Gamma-synuclein, working memory, passive-avoidance test, and amphetamine induced locomotion, soluble proteins, neural tissue.


Institute of Biomedical Problems RAS, Moscow, Specialized Multidisciplinary Hospital №1 of Ukrainian Ministry of Health, Dnipro, Institute of Physiologically Active Compounds RAS, Chernogolovka, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str., 8, bld. 2, Moscow, 119991, Institute of Physiologically Active Compounds RAS, Chernogolovka, Institute of Physiologically Active Compounds RAS, Chernogolovka

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