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Voltage-gated Sodium Channels Involved in Sensory Information Processing


You Zhou and Yonghua Ji*   Pages 1 - 6 ( 6 )


Objective & Background: Action potential is a form of electric signaling responsible for conducting neural firing in organisms. Voltage-gated sodium channels (VGSCs) are key molecules dedicated to the initiation and propagation of action potentials, playing an indispensable role in processing excitable activity. The foundational sensory of human covering vision, auditory, olfactory, taste and tactile perceive the outer world rely on normal physiological function of VGSCs, which play as a root dancing in music of life. The aberrant genetics and endogenous regulation of VGSCs in most cases give rise to related clinical symptom such as hyperpselaphesia, parosphresia, and so on. Conclusion: This review highlights recent advances in the study of VGSCs in sensory systems which may facilitate the fresh understanding of VGSCs in sensory information processing and provide a novel pharmacological target for the treatment of sensory system related clinical disease.


Voltage-gated sodium channel, action potential, information processing


Shanghai University - Laboratory of Neuropharmacology and Neurotoxicology Shanghai, Shanghai University - Laboratory of Neuropharmacology and Neurotoxicology Shanghai

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