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Voltage-gated Sodium Channels in Sensory Information Processing

[ Vol. 18 , Issue. 4 ]

Author(s):

You Zhou, Ping Pan, Zhi-Yong Tan and Yonghua Ji*   Pages 273 - 278 ( 6 )

Abstract:


Objective & Background: Voltage-gated sodium channels (VGSCs) and potassium channels are critical in the generation of action potentials in the nervous system. VGSCs and potassium channels play important roles in the five fundamental senses of vision, audition, olfaction, taste and touch. Dysfunctional VGSCs are associated with clinical sensory symptoms, such as hyperpselaphesia, parosphresia, and so on.

Conclusion: This short review highlights the recent advances in the study of VGSCs in sensory information processing and discusses the potential role of VGSCs to serve as pharmacological targets for the treatment of sensory system diseases.

Keywords:

Voltage-gated sodium channel, action potential, information processing.

Affiliation:

Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai 200444, Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai 200444, Department of Pharmacology and Toxicology and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai 200444



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