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Monoamine Involvement in the Antidepressant-Like Effect of β-Caryophyllene

[ Vol. 17 , Issue. 4 ]

Author(s):

Danillo Ramos de Oliveira, Dayane Moreira da Silva, Iziara Ferreira Florentino, Adriane Ferreira de Brito, James Oluwagbamigbe Fajemiroye, Daiany Priscilla Bueno da Silva, Fabio Fagundes da Rocha, Elson Alves Costa and Pablinny Moreira Galdino*   Pages 309 - 320 ( 12 )

Abstract:


Background: Major depressive disorder is a psychiatric disorder that affects 4.4% of the population worldwide. Although the majority of antidepressant drugs ameliorate depressive symptoms, there is still a need for safer and more effective antidepressant.

Objective: Evaluate the antidepressant-like activity of sesquiterpene compound β-caryophyllene (BCP) for the possible contribution of the monoamine and hippocampal levels of brain-derived neurotrophic factor (BDNF).

Methods: Male albino Swiss mice were subjected to the forced swimming test after acute treatment and to the tail suspension test after repeated treatment. Hippocampal levels of BDNF were assayed by enzyme-linked immunosorbent assay.

Results: The anti-immobility effect of BCP was reverted by pretreatment with an inhibitor of catecholamine synthesis α-methyl-p-tyrosine (100 mg/kg, i.p.), α2-adrenergic antagonist yohimbine (1 mg/kg, i.p.), and β-adrenergic antagonist propranolol (2 mg/kg, i.p.), but not by pretreatment with either α1-adrenergic antagonist prazosin (1 mg/kg, i.p.) or 5-HT1A antagonist NAN-190 (0.5 mg/kg, i.p.), thereby suggesting the involvement of α2 and β-adrenergic receptors, but not of the α1-adrenergic and 5-HT1A serotonergic receptors, in BCP's antidepressive-like activity. Furthermore, BCP increased BDNF levels in the hippocampus after 14 days of treatment. No treatments in this study altered locomotor activity in the open field test.

Conclusion: This study provides a new mechanism of BCP-induced antidepressant-like effect mediated by some sub-types of catecholaminergic neurotransmitter system that could be a candidate for clinical tests of new treatments for depressive disorders.

Keywords:

Antidepressant-like effect, β-caryophyllene, behavioral test, monoamines, Major depressive disorder, Hippocampal levels.

Affiliation:

Programa de Pos-Graduacao em Ciencias Farmaceuticas, Faculdade de Farmacia, Universidade Federal de Goias, Goiania, GO, Programa de Pos-Graduacao em Ciencias Biologicas, Instituto de Ciencias Biologicas, Universidade Federal de Goias, Goiania, GO, Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas e da Saude, Universidade Federal Rural do Rio de Janeiro, Seropedica, RJ, Programa de Pos-Graduacao em Ciencias Biologicas, Instituto de Ciencias Biologicas, Universidade Federal de Goias, Goiania, GO, Programa de Pos-Graduacao em Ciencias Biologicas, Instituto de Ciencias Biologicas, Universidade Federal de Goias, Goiania, GO, Programa de Pos-Graduacao em Ciencias Biologicas, Instituto de Ciencias Biologicas, Universidade Federal de Goias, Goiania, GO, Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas e da Saude, Universidade Federal Rural do Rio de Janeiro, Seropedica, RJ, Departamento de Farmacologia, Instituto de Ciencias Biologicas, Universidade Federal de Goias, Goiania, GO, Centro de Ciencias Biologicas e da Saude, Universidade Federal do Oeste da Bahia, Barreiras, BA

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