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TNF-α Polymorphisms and Maternal Depression in a Mexican Mestizo Population

[ Vol. 17 , Issue. 1 ]

Author(s):

Ada Sandoval-Carrillo, Cosme Alvarado-Esquivel, Carlos Salas-Martinez, Edna M. Mendez-Hernandez, Antonio Sifuentes-Alvarez, Ana L. Martínez-Martinez, Juan M. Castillo-Orona, Jesus Hernandez-Tinoco, Elizabeth I. Antuna-Salcido, Luis F. Sanchez-Anguiano, Lilia M. Velez Velez, Sergio M. Salas-Pacheco, Francisco X. Castellanos-Juarez, Osmel La Llave-Leon, Oscar Arias-Carrion* and Jose M. Salas-Pacheco*   Pages 69 - 74 ( 6 )

Abstract:


Background: Depressive disorders are common during pregnancy. There is compelling evidence that the inflammatory response system is important in the pathophysiology of depression. Higher concentrations of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-α) in depressed subjects have been described. Because several polymorphisms in the TNF-α promoter region are known to affect its gene expression, the aim of this study was determine whether TNF-α - 857C/T, -308G/A, and -238G/A polymorphisms confer susceptibility to depression during pregnancy in a Mexican mestizo population.

Methods: This case-control study involved 153 depressed pregnant women and 177 controls. Polymorphisms were genotyped using real-time PCR. Odds ratios (OR) and 95% confidence intervals adjusted by age, body mass index, number of pregnancies, months of pregnancy and number of abortions were used to estimate risk.

Results: The -857CT genotype was found to increase the risk for depression (OR= 1.73, 95% CI= 1.06-2.82). In contrast, the -238GA genotype reduced the risk (OR= 0.33, 95% CI= 0.14-0.72). The - 308G/A polymorphism was not associated with risk for depression. Finally, the C857-G308-A238 haplotype was associated with a decreased risk of depression (OR= 0.35, 95% CI= 0.15-0.82).

Conclusion: Our results show for the first time an association between TNF-α -857C/T and -238G/A polymorphisms and prenatal depression in Mexican mestizo population.

Keywords:

Depressive disorders, prenatal depression, tumor necrosis factor-alpha, TNF-α, polymorphism, risk population.

Affiliation:

Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Durango, Facultad de Medicina y Nutricion, Universidad Juarez del Estado de Durango, Durango, Facultad de Medicina y Nutricion, Universidad Juarez del Estado de Durango, Durango, Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Durango, Facultad de Medicina y Nutricion, Universidad Juarez del Estado de Durango, Durango, Facultad de Medicina y Nutricion, Universidad Juarez del Estado de Durango, Durango, Facultad de Medicina y Nutricion, Universidad Juarez del Estado de Durango, Durango, Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Durango, Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Durango, Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Durango, Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Durango, Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Durango, Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Durango, Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Durango, Unidad de Trastornos del Movimiento y Sueno, Hospital General Dr. Manuel Gea Gonzalez, Ciudad de Mexico, Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Durango

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