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Oxidation of Potassium Channels in Neurodegenerative Diseases: A Mini- Review

[ Vol. 17 , Issue. 4 ]

Author(s):

Junsheng Yang* and Xueni Yan   Pages 267 - 271 ( 5 )

Abstract:


Background & Objective: Increased level of reactive oxygen species is a hallmark of common neurodegenerative diseases such as Alzheimer’s Disease and Parkinson’s Disease. ROS can oxidize macromolecules including DNA, lipids and proteins and cause oxidative damage to the cell. Emerging evidence indicate that potassium channels in the central nervous system are no exceptions to these oxidative modifications.

Conclusion: In this mini-review, we summarized recent reports on the oxidation of potassium channels in the CNS and the consequently resulted changes in cell functions and viability, with focus on its implications in neurodegenerative diseases.

Keywords:

Aging, neurodegenerative diseases, oxidation, potassium channel, reactive oxygen species (ROS), lipids and proteins.

Affiliation:

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014

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