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Role of Epigenetics and Oxidative Stress in Gliomagenesis

[ Vol. 16 , Issue. 10 ]

Author(s):

Yesennia Sanchez-Perez, Ernesto Soto-Reyes, Claudia M. Garcia-Cuellar, Bernardo Cacho-Diaz, Abel Santamaria and Edgar Rangel-Lopez*   Pages 1090 - 1098 ( 9 )

Abstract:


Background & Objective: Gliomas constitute 81% of malignant brain tumors and exhibit a poor prognosis. Two main events involved in the progression of gliomas are the deregulation of genes via genetic events and the cellular damage resulting from the formation of reactive oxygen species (ROS). In gliomas, epigenetic abnormalities implicated in the deregulation of deoxyribonucleic acid (DNA) methylation, nucleosome rearrangement, and acetylation of histones, have been depicted. The overproduction of ROS has been implicated in the promotion of these modifications.

Conclusion: In this review, we discuss the epigenetic mechanisms and oxidative events that impact gene silencing and its association with the establishment and development of gliomas. Some of these epigenetic marks, or their related proteins, are under investigation for their potential use as biomarkers in clinical trials to propose personalized therapies for patients with glioblastoma.

Keywords:

Brain tumors, clinical trials, epigenetics, glioma, malignant, oxidative stress.

Affiliation:

National Cancer Institute, Subdirection of Basic Research, Laboratory of Epigenetic and Environment, Av. San Fernando #22 Col. Seccion XVI. Delegacion Tlalpan, C.P 14080 Mexico City, National Cancer Institute, Subdirection of Basic Research, Laboratory of Carcinogenesis, Av. San Fernando #22 Col. Seccion XVI. Delegacion Tlalpan, C.P 14080 Mexico City, National Cancer Institute, Subdirection of Basic Research, Laboratory of Carcinogenesis and Environmental, Av. San Fernando #22 Col. Seccion XVI. Delegacion Tlalpan, C.P 14080 Mexico City, National Cancer Institute, Department of Neurology, Neurophysiology & Neuro-oncology. Av. San Fernando #22 Col. Seccion XVI. Delegacion Tlalpan, C.P 14080 Mexico City, National Institute of Neurology and Neurosurgery, Laboratory of Excitatory Amino Acids. Av. Insurgentes Sur #3877 Col. La Fama. Delegacion Tlalpan, C.P. 14269 Mexico City, National Institute of Neurology and Neurosurgery, Laboratory of Excitatory Amino Acids. Av. Insurgentes Sur #3877 Col. La Fama. Delegacion Tlalpan, C.P. 14269 Mexico City

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