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Advances in Therapies of Cerebellar Disorders: Immune-mediated Ataxias

Author(s):

Marios Hadjivassiliou*   Pages 1 - 9 ( 9 )

Abstract:


The identification of an increasing number of immune mediated ataxias suggests that the cerebellum is often a target organ for autoimmune insults. The diagnosis of immune mediated ataxias remains challenging as there is significant clinical overlap between immune mediated and other forms of ataxia. Furthermore the classification of immune mediated ataxias requires further clarification particularly for those ataxias where no specific antigenic trigger and associated antibodies have been identified. Recognition of immune mediated ataxias remains imperative as therapeutic interventions can often be effective, although given the relative rarity of this entity, large-scale treatment trials may not be feasible. This review will discuss advances in therapies for immune mediated ataxias based on what is currently available in the literature.

Keywords:

cerebellar ataxia, gluten ataxia, paraneoplastic cerebellar degeneration, primary autoimmune cerebellar ataxia

Affiliation:

Royal Hallamshire Hospital



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