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Mitochondrial Dysfunctions in Bipolar Disorder: Effect of the Disease and Pharmacotherapy

[ Vol. 16 , Issue. 2 ]

Author(s):

Tereza Cikankova, Ekaterina Sigitova, Martina Zverova, Zdenek Fisar, Jiri Raboch and Jana Hroudova   Pages 176 - 186 ( 11 )

Abstract:


Exact pathophysiological mechanisms of bipolar disorder have not been sufficiently clarified. We review the evidence of mitochondrial dysfunctions on the relation between both disease and pharmacotherapy. Mitochondria produce the most of energy-rich molecules of adenosine triphosphate (ATP), apart from energy production they are involved in other functions: regulation of free radicals, antioxidant defenses, lipid peroxidation, calcium metabolism and participate in the intrinsic pathway of apoptosis. According to increasing evidence dysfunctions of mitochondria are associated with affective disorders, a hypothesis of impaired mitochondrial functions has been proposed in bipolar disorder pathogenesis. Mitochondrial DNA mutations and/or polymorphisms, impaired phospholipid metabolism and glycolytic shift, decrease in ATP production, increased oxidative stress and changes of intracellular calcium are concerned in mood disorders and effects of mood stabilizers. Recent studies have also provided data about the positive effects of chronic treatment by mood stabilizers on mitochondrial functions.

Keywords:

Bioenergetics, bipolar disorder, electron transport chain complexes, mitochondria, mitochondrial DNA, mood stabilizers, oxidative phosphorylation.

Affiliation:

Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2

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