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Lipoxygenase: An Emerging Target for Stroke Therapy

[ Vol. 12 , Issue. 2 ]

Author(s):

Klaus van Leyen   Pages 191 - 199 ( 9 )

Abstract:


Neuroprotection as approach to stroke therapy has recently seen a revival of sorts, fueled in part by the continuing necessity to improve acute stroke care, and in part by the identification of novel drug targets. 12/15- Lipoxygenase (12/15-LOX), one of the key enzymes of the arachidonic acid cascade, contributes to both neuronal cell death and vascular injury. Inhibition of 12/15-LOX may thus provide multifactorial protection against ischemic injury. Targeting 12/15-LOX and related eicosanoid pathways is the subject of this brief review.

Keywords:

Ischemic stroke, neuroprotection, oxidative stress, eicosanoid, lipoxygenase, arachidonic acid cascade.

Affiliation:

Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, 149 13th St., R. 2401, Charlestown, MA 02129, USA.



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